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United States can secure their place in the 2022 World Cup when they host Panama in their penultimate qualifying match.
The USMNT sit second in the group and need a win to guarantee a spot in the finals tournament.
Panama, however, are still hoping to steal the inter-continental play-off place as they sit one point behind Costa Rica.
United States vs Panama latest odds
Both of these teams drew in their previous matches and the tie here is available at 7/2 (4.5).
United States vs Panama preview
Panama pulled off a shock victory when they hosted the USMNT in October last year.
It is one of just two defeats that Gregg Berhalter's team have suffered in this campaign.
The home side have just endured an energy-sapping draw against Mexico this week and could be exhausted heading into this tie.
Timothy Weah and DeAndre Yedlin are both unavailable through suspension.
Yedlin being out, plus the absence of Reggie Cannon and Sergino Dest gives Berhalter a bit of a conundrum to sort out at right-back.
Panama, meanwhile, were held to a draw by bottom side Honduras in their most recent game, resulting in Costa Rica moving into the play-off place.
That slip up could put an end to their hopes of going through as they are not expected to get any points from their final two matches - against USA and Canada.
United States vs Panama tips & predictions
Under 2.5 goals is priced at 17/20 (1.85) and is an attractive bet given we could be in for a tight affair in Orlando, Florida.
Odds correct at the time of writing. 18+. begambleaware.org