As with any derby encounter, there are subplots and the following five players, in particular, will be desperate to prove a point when Pirates play host to Chiefs at the 2010 Fifa World Cup training venue Orlando Stadium.
There have been doubts about Pirates striker's ability to deliver in big games having failed to score against Mamelodi Sundowns and Chiefs this season having started the matches.
Peprah also endured a four-match goal drought which led to him being relegated to the bench against Libya's Al-Ittihad last month, but he did score on his return to the starting line-up against minnows Royal Leopards of Eswatini.
The left-footed striker, who scored 12 goals and provided 10 assists from 32 Ghanaian Premier League games last term, will be determined to show that he has Big Match Temperament when he faces the mighty Amakhosi.
The 24-year-old full-back lost his place in Chiefs starting line-up as the club's first-choice right-back following coach Stuart Baxter's arrival at Naturena-based giants in June last year.
However, Sifiso Hlanti's long-term injury and Siphosakhe Ntiya-Ntiya's loss of form has given Frosler a chance to enjoy regular game time this year.
The Soweto Derby is the perfect platform for the two-footed player to impress and prove to Baxter that he is should be a permanent fixture in the starting line-up.
There were calls for the experienced goalkeeper to be dropped after he conceded five goals in two Caf Confederation Cup games last week.
Mpontshane did keep a clean sheet against Cape Town City on Wednesday, but there are those who still feel that the 36-year-old is not fit to be starting games in the absence of the club's first-choice keeper Richard Ofori, who is nursing a long-term injury.
A brilliant performance in the Soweto Derby would go a long way towards silencing the 2014/15 Telkom Knockout Player of the Tournament nominee's critics.
Cole Alexander's injury and Njabulo Blom's redeployment to right-back or right wing-back has given Baccus an opportunity to finally cement his place in Chiefs' starting line-up.
Baccus has started two league games this season and the Glamour Boys won both games including the most recent one which was against Baroka FC last weekend as one of the standout performers.
The gifted midfield maestro has to show he is of the quality of Chiefs' star players Khama Billiat and Keagan Dolly and it is in the big games when players display their class.
The hard-working midfielder has surprisingly lost his place in Pirates' starting line-up since the turn of the year with Goodman Mosele and Thabang Monare being the preferred midfield pairing.
Motshwari has been mainly used as an impact player coming from the bench, but he is now set to start in the absence of Mosele, who will be serving his suspension.
The Randfontein-born will want to stamp his authority in midfield and show his undeniable quality against Chiefs in order to re-cement his place in the team.
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