Pieterse comes in to replace Kennedy Mweene who has been rested for the Al Ahly game.
The defender will be deployed in a three-man defence to help stop the third-tier side.
The Cape Town-born defender will make his 22nd appearance across all competitions for Sundowns this season.
He has come in to replace Brian Onyango who has been a regular in recent matches.
Modiba gets his chance and will be playing as a right wing-back for Masandawana.
The Zimbabwe international has a chance of proving his worth as he takes the left wing-back position.
The 26-year-old midfielder had a decent outing against Maritzburg and will feature in his first Nedbank Cup match of the season after being overlooked in the Round of 32.
Ralani will be playing just in front of Mkhulise in midfield.
Maema completes the midfield trio for the Brazillians.
Tuesday's skipper has been handed a role just behind the main striker as Peter Shalulile takes a rest.
Kutumela has been given an opportunity to lead the attacking department.
Copyright © 2022 Goal (Singapore) All rights reserved. The information contained in Goal (Singapore) may not be published, broadcast, rewritten, or redistributed without the prior written authority of Goal (Singapore)