The dissection has already begun.
Barcelona travelled to the Italian capital on Tuesday evening clutching a three-goal advantage but will return to Catalunya empty-handed.
However, a 3-0 victory for the Serie A side at Stadio Olimpico in the decisive leg sent Roma through in their place, with the result sparking jubilation in Italy but devastation in Spain.
But how did the national papers react to the results? Goal takes a look.
MARCA - TOTAL FAILURE IN EUROPE
SPORT - FAILURE WITHOUT EXCUSES
AS - CULES BUMPED
TUTTOSPORT - ROMA ECSTASY
MUNDO DEPORTIVO - THE FALL OF ROMA
CORRIERE DELLO SPORT - Rome in the myth