The top two spots in the group are currently occupied by Betis and Milan but, with Olympiakos taking on minnows Dudelange, Thursday's game in Spain could be very important.
Betis came out on top the last time these two sides met when winning 2-1 at San Siro a fortnight ago.
|Game||Real Betis vs AC Milan|
|Date||Thursday, November 8|
|Time||8:00pm GMT / 3:00pm ET|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial) .
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Univision Deportes Network||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on BT Sport ESPN and livestreamed on BT Sport Live.
|UK TV channel||Online stream|
|BT Sport ESPN||BT Sport Live|
Squads & Team News
|Position||Real Betis players|
|Defenders||Mandi, Sidnei, Feddal, Gonzalez, Barragan, Firpo, Bartra|
|Midfielders||Boudebouz, Guardado, Garcia, Canales, Guerrero, Inui, Kaptoum, Carvalho, Joaquin, Lo Celso|
|Forwards||Tello, Moron, Gonzalez, Leon, Sanabria, Altamirano|
Confirmed Real Betis XI: Pau Lopez, Mandi, Bartra, Feddal, Tello, Lo Celso, William Carvalho, Canales, Junior Firpo, Joaquin, Sanabria.
|Position||AC Milan players|
|Defenders||Romagnoli, Rodriguez, Musacchio, Caldara, Abate, Zapata, Calabria, Strnic, Simic|
|Midfielders||Calhanoglou, Castillejo, Bonaventura, Biglia, Bakayoko, Montolivo, Laxalt, Kessie, Bertolacci, Halilovic, Conti|
|Forwards||Higuain, Cutrone, Suso, Borini|
Gonzalo Higuain will miss the game as he continues to be troubled by a hip injury, so Patrick Cutrone will be looked upon to score the goals.
Mattia Caldara and Ivan Strnic are both long-term absentees, Giacomo Bonaventura, Davide Calabria and Lucas Biglia are all unavailable, while Samu Castillejo is suspended.
Confirmed AC Milan XI: Reina, Musacchio, Zapata, Rodriguez, Borini, Kessie, Bakayoko, Calhanoglu, Laxalt, Suso, Cutrone.
Betting & Match Odds
The bookies are anticipating a tight affair as Bet365 have Real Betis as favourites at 6/5, the draw is 12/5 and AC Milan are the outsiders at 13/5.
Despite Real Betis' poor league form they find themselves top of their Europa League group after beating AC Milan last time out.
Milan have been strong in Serie A of late and are coming off the back of three consecutive league wins.
Group F could be blown wide open, though, depending on the result in the Olympiakos game where the Greek side face off against the weakest team in the group Dudelange.
Milan's long injury list will hinder their chances of getting a result as star man Higuain will have to watch from the sidelines.
A lot of pressure will be on Cutrone's shoulders as the young striker will be leading the line in a crucial Europa League game.
The 20-year-old has struck three times already in the Europa League this season and will be hoping that he can add to his tally on Thursday.