Spurs make the trip to Selhurst Park on Saturday for what will be their fifth game in 13 days and last before the November internationals.
Unsurprisingly, Pochettino said he would prefer to keep his players at the club, but added how he managed them would be crucial.
"That is why we need to take care and send them really fresh. That is why we are thinking if they are going to play or not against Palace.
"It is true if you said to me would you prefer all my international players stay here and rest for two weeks without competition, I would say yes. But that is impossible.
"That is why we were talking before about Dele Alli and Christian Eriksen and international duty. It is play, play, then move them there and play again. If you see our schedule for the next few months it will be so tough."