The 31-year-old centre-back started all four games for Argentina at last year's World Cup as Jorge Sampaoli's side were knocked out by France in the last 16.
His City team-mate Sergio Aguero was a surprise omission from Argentina's squad despite topping the Premier League's scoring charts with 18 goals.
Lionel Scaloni has been placed in charge until after the Copa America this summer but has been without a handful of senior players.
But Angel di Maria and Gonzalo Higuain continue to be omitted, while ostracised Inter forward Mauro Icardi has also been overlooked for the international double-header.
In his six games in charge, Scaloni has won four, drawn one and suffered one defeat to Brazil back in October.