Javi Calleja's side secured a comprehensive win at the Estadio de la Ceramica with a dominating display that produced three first-half goals.
Ekambi set up Pablo Fornals for Villarreal's opening goal in the 26th minute. Four minutes later, the 26-year-old doubled the lead with his second effort in the Europa League this campaign.
The Cameroonian forward who switched to the Spanish top-flight outfit in the
After the restart, the former Angers talisman continued his fine display with another assist for Dani Raba who fired in a fourth goal for the Yellow Submarine.
Meanwhile, Nigeria's Samuel Chukwueze was thrown into the fray for Fornals in the 69th minute but the hosts were reduced to 10 men after Jaume Costa was shown a second yellow card in the 79th minute.
#UEL | 5-0 🚨 85' | GOOOOOOOOOOOOOOOAAAAAAAAAAAAAAAAAALLLLLLLLLLLLLLL!!! AND IT'S 5!!! @GerardMoreno9 hits the back of the net after a great pass forward by @chukwueze_8! Great team play! 👏👏👏👏 pic.twitter.com/PL4IFUUPjJ— Villarreal CF English (@Eng_Villarreal) October 25, 2018
Despite the numerical shortage, the Spanish side held their nerves with Chukwueze assisting fellow substitute Gerard Moreno to seal the win with the fifth goal in the 85th minute.
The victory moved Villarreal to the summit of the group levelled on points with Rangers - five points from three games.