Sundowns on other hand, will be out to end their winless streak and get their campaign back on track.
As things stand, Sundowns are placed eighth on the log after three league game, while Usuthu find themselves in position seven after four matches.
|Game||AmaZulu v Sundowns|
|Date||Sunday, September 16|
|Time||3:00 pm SA Time|
TV Channel, Live Score & How To Watch
|Live Match Centre||TV Channel|
Squads & Team News
|Goalkeeper||Denis Onyango (injured)|
|Strikers||Anthony Laffor (injured)|
Sundowns have confirmed that they will be without goalkeeper Denis Onyango and attacker Anthony Laffor for this encounter, but other than the two players, Mosimane has all the players to choose from.
In the absence of Onyango, Mosimane is likely to call on Kennedy Mweene, who has shown maturity and hunger when he's given the opportunity.
Sundowns' attack is unlikely to feel Laffor's absence that much simply because of the quality and depth in that department.
Predicted Sundowns XI: Mweene, Ngcongca, Langerman, Nascimento, Madisha, Kekana, Manyisa, Vilakazi, Sirino, Silva, Brockie.
Meanwhile, AmaZulu have not reported any injuries from their camp ahead of this match.
Cavin Johnson's men started the season well although they find themselves in position seven. The former Sundowns employer will want to pile more misery on the Tshwane giants.
Sundowns recently crashed of two Cup competitions - Caf Champions League and MTN8 - something which very few people expected.
Predicted AmaZulu XI: Josephs, Sikhakhane, Mabiliso, Nyongo, Gumede, Ncube, Vilakazi, Ramphela, Ncobeni, Tade, Khenyeza.
Based on form, AmaZulu have the advantage over Sundowns, but in head-to-head stats, Mosimane's men are just too strong for the Durban-based outfit.
In the last five matches, including those that were played last season, AmaZulu have won three and lost two.
Sundowns on the other hand, have lost three matches and drawn two.
Looking at the head-to-head stats, the last 10 matches between the two sides have seen Sundowns win eight to Usuthu's just two.