The Omonoia Nicosia goalkeeper gets the nod to start while Maduka Okoye rests after playing the last two games.
The Paderborn left-back reported late to Cameroon but has been given a chance to make his mark in Austin Eguavoen's team on Wednesday.
Troost-Ekong continues with his responsibility as the team leader while Ahmed Musa is expected to start as a substitute
The West Bromwich Albion defender played some minutes in Nigeria's 1-0 win over Egypt and he has been named in the starting XI against Guinea Bissau.
The Italy based star is expected to prove that he is capable of dethroning Ola Aina as Super Eagles' most-preferred right-back.
Unarguably the engine room in the Super Eagles' midfield. His tackles and interceptions is needed to stop any threat from the Djurtus.
The Everton man is expected to establish his presence in the midfield. He will surely be the creative link with his distribution of passes, dribbles and keeping possession.
The Spain-based youngster has been handed his first start in the Africa Cup of Nations against Guinea Bissau. Should he live up to expectations, he could cement his place in the three-time African champions' side.
The pacy CSKA Moscow forward could prove crucial against the Djurtus as he will be expected to disturb the Guinea-Bissau defence.
Upfront, Iheanacho has been playing the backup role efficiently with his positioning and runs.
Sadiq struggled to make an impact after coming on as a substitute in the final 10 minutes of Saturday's win.
However, the Almeria striker will be hoping to show his qualities having seen Taiwo Awoniyi start the first two games.
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