In contrasting results in their respective domestic leagues, the Magpies ended a three-game losing run with a 1-0 win over Brentford, while the Rossoneri's three-game winning run was was snapped when they went down 5-1 to Inter Milan last weekend.
With PSG and Dortmund in the group, every game in Group F would be a must-win for all sides involved here.
Here GOAL brings you everything you need to know about how to watch, including TV channel, streaming details and more.
AC Milan vs Newcastle kick-off time & stadium
|Date:||September 19, 2023|
|Kick-off time:||5:45pm BST|
Venue and timing of the match between AC Milan and Newcastle United will be played at the San Siro football stadium in Milan, Italy.
It will kick off at 5:45pm BST on September 19 in the United Kingdom (UK).
How to watch AC Milan vs Newcastle online - TV channels & live streams
Fans who are unable to watch the game can follow the live updates on GOAL.
Team news & squads
AC Milan team news
Christian Pulisic is reportedly set to be dropped to the bench for AC Milan's Champions League opener against Newcastle. As such, Samuel Chukwueze is likely to get the nod to feature alongside Olivier Giroud and Rafael Leao.
Stefano Pioli would continue to be without the services of center-back Pierre Kalulu due to a thigh problem, but Fikayo Tomori would return from suspension to possibly replace Mallick Thiaw at the back.
Meanwhile, Ismael Bennacer is a long-term absentee after a knee surgery.
AC Milan possible XI: Maignan; Calabria, Tomori, Kjaer, Hernandez; Reijnders, Krunic, Loftus-Cheek; Chukwueze, Giroud, Leao
|Goalkeepers:||Maignan, Sportiello, Nava, Mirante|
|Defenders:||Tomori, Kalulu, Thiaw, Kjaer, Caldara, Pellegrino, Hernandez, Calabria, Florenzi|
|Midfielders:||Bennacer, Loftus-Cheek, Musah, Reijnders, Pobega, Krunic, Adli, Pulisic, Saelemaekers, Romero|
|Forwards:||Okafor, Giroud, Leao, Chukwueze, Traore, Jovic|
Newcastle team news
Sandro Tonali will be raring to face his former side after making it to the bench against Brentford, with Elliott Anderson to drop out as a result, while Alexander Isak is likely to replace Callum Wilson at the center-forward position.
However, Newcastle boss Eddie Howe's concern would be around Joelinton's availability as the midfielder picked up a knock to his knee while on Brazil duty, but Joe Willock and Emil Krafth are sure to miss out through injuries.
Newcastle possible XI: Pope; Trippier, Schar, Botman, Burn; Longstaff, Tonali, Guimaraes; Gordon, Isak, Barnes
|Goalkeepers:||Pope, Dubravka, Karius, Gillespie|
|Defenders:||Botman, Schar, Lascelles, Targett, Hall, Burn, Dummett, Livramento, Trippier, Manquillo|
|Midfielders:||Guimaraes, Tonali, Joelinton, Longstaff, Longstaff, Miley, Ritchie, Anderson, Almiron, Murphy|
|Forwards:||Barnes, Gordon, Isak, Wilson|
This will be the first time AC Milan and Newcastle United face each other across all competitions.